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These pale areas were present even outside the area that was ligated, and many gross mucosal defects were present in the enlarged colon segment (Table 2, Figure 20)

A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

The calculation can also be done using minerals that are not affected by the chemical treatment regime, such as chloride or silica

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