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Description
Several interrelated mechanisms likely underlie this dysregulation, including the hyperglycemic microenvironment, insulin resistance, chronic oxidative stress, and progressive renal structural damage, which collectively impair carnitine homeostasis through multidimensional and cascading pathophysiological mechanisms

The effect of L-carnitine on weight loss: A systematic review and meta-analysis of randomized controlled trials

Our laboratory contributed to the molecular understanding of the catalytic mechanism of the enzyme which comprises the Rieske-type oxygenase CntA and the corresponding reductase CntB (Massmig et al., 2020

doi: 10.1097/00005768-200003000-00024
