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Neuronal deletion of the PTP1B gene results in decreased food intake and increased energy expenditure [145, 146]

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A pH-sensitive, negatively charged polymer, dimethylmaleic anhydride (DA)-modified poly(ethylene glycol)-epsilon-poly(L-lysine) (PEG-PLL-DA), was synthesized using cholesteryl hemisuccinate (CHEMS) as a counterion and used to coat the positively charged NPs, effectively masking their surface charge

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