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In vitro experiments indicate that stimulating FOXO3 expression significantly decreases the generation of ferroptosis-related markers like MDA, suggesting its potential to suppress OA progression (Zhao et al., 2023)

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19 However, over the last decade, the focus has shifted from comparing generic necrosis and apoptosis to exploring the signaling mechanisms of various necrotic cell death pathways

Post-translational modification affects the stability of GPX4 proteins by modulating the degradation of GPX4