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Description

41 We will pilot the test in the current study setting ahead of study start to ensure that it is appropriate for the study setting

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GMC, GDC, NMC, HCPC, GPhC

Interestingly, PNPLA3 I148M is not properly targeted by the UPS which likely promotes the disease-causing variant to accumulate on LDs (135) where it can disrupt protein-protein interactions critical for TAG hydrolysis (70, 75)