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Description
Exercising artistic license here, the below graph with the lilac-shaded area at the right takes the Morning point (A) point and replays it at the right end of the graph as (A*)

It has been shown that exercise causes MOTS-c levels to go up in humans

4 Studies of individuals after bariatric surgery show strong evidence of the importance of significant weight loss in improving metabolic disorders

Peer review Peer review information Nature Reviews Drug Discovery thanks Timo Mller and the other anonymous reviewer/s for their contribution to the peer review of this manuscript