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Levels of FABP rise rapidly after GI inflammation and have been correlated with the histological status of the epithelium after GI inflammation

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However, a later study found MORs specifically inhibit midline thalamus inputs to layers 2/3 and layer 5 anterior cingulate cortex pyramidal neurons and parvalbumin (PV)-expressing interneurons

To assess these effects, we shifted our primary focus to cellular activity in the presence of serum and measured at a later time point (16 hours) as it represented a more physiological condition