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Patients previously treated with a triple combination of peginterferon, ribavirin, and an NS3/4A protease inhibitor can be treated anew with sofosbuvir/ledipasvir (26), sofosbuvir/velpatasvir (24), or sofosbuvir/daclatasvir (27) without any compromise of the likelihood of a sustained virological response

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling

More broadly, these findings show that by buffering toxic lipids and sequestering selected drugs, the metabolic plasticity provided by LD remodeling supports cancer cell survival under treatment stress and leads to therapy resistance