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10.1007/s00467-018-4005-4 10 DjudjajS.BoorP
The endothelial cells are capable of endocytosing many ligands and also may secrete cytokines when appropriately stimulated
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When the oxidative stress state persists and the damage progresses, senescent cells enter a senescent state marked by p16 upregulation, which consequently inhibits the kinases CDK4 and CDK6, thereby maintaining the stagnant state of the cell cycle [133, 134]
