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LPS binds to Toll-like receptor 4 (TLR4) on the surface of Kupffer cells, activating both the MyD88-dependent pathway, which mediates NF-B signaling, and the MyD88-independent pathway involving interferon regulatory factor 3 (IRF3), ultimately upregulating TNF- transcription [49, 50]

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However, it is still unknown whether providing the KD after stroke injury would be protective and whether the mechanisms of neuroprotection differ between providing the KD pre-injury or post-injury