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doi: 10.1007/978-1-4419-8216-2_7 498 ManianFA

These localized areas of ablation and the delivered heat activate the inherent healing capacity of the skin, spearheaded by fibroblasts, that stimulates the production of new collagen and elastin fibers and rearrangement and realignment of existing collagen

Indeed, the absence of microbiota determines an impaired function of neutrophils and DC, with reduced killing of pathogens and secretion of Interferon-I (IFN-I) and IL-15 [35]

Furthermore, the human AD gut microbiota promotes an intestinal inflammatory state by lowering P-glycoprotein expression and slightly elevating MRP2 protein levels in cultured intestinal epithelial cells, thus modulating inflammatory responses against commensals [329]