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serine-glycine withdrawal dampens nucleotide synthesis via a similar mechanism 389

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Although fumarate has been demonstrated to exert a pivotal role in cellular metabolism and signaling, further research is necessary to elucidate the intricate interactions between fumarate, the TCA cycle, mtDNA, and neuronal functioning

Based on these mechanistic understandings, it is evident that folate deficiency can play an important role in the development of major neurodegenerative diseases such as AD, PD, MS, ALS, and HD