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Second, a reduction in tubular reabsorption of both free carnitine and acylcarnitine has been reported during VPA treatment [45,46], Third, VPA reduces endogenous synthesis of carnitine by blockade of the enzyme butyrobetaine hydroxylase

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[Google Scholar] 19.Dionyssopoulou E, Vassiliadis S, Evangeliou A, Koumantakis EE, Athanassakis I