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Description
Weight gain and increased central obesity in the early phase of Parkinson's disease

Peroxyl radical leads to enzyme inactivation and protein aggregation, linked to neurodegenerative like Alzheimers and Parkinsons diseases

This work has been extended to the determination of a number of enzyme complex crystal structures which show that very large ligands are readily accommodated into this substrate binding site and in all, but one case, causes no significant movement of protein side-chains

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