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The importance of -KG and DNA demethylation during T cell exhaustion is exemplified by the finding that CD8 T cells deficient in TET2 maintain a T pex phenotype with reduced expression of terminal exhaustion markers like TOX, CD39, and 2B4 during chronic infection [73,74]
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doi: 10.1038/s41591-018-0309-y
The role of zinc in modulating oxidative stress has recently been recognized
