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However, melatonin is not exclusively produced in the pineal gland, but it is also locally synthesized in several cells and tissues, such as the retina, the gastrointestinal tract, and the innate immune system 10

This activity of IRE1 is independent of its role in regulating the UPR and is evolutionarily conserved

Discussion In this network meta-analysis incorporating data from twenty-two randomised trials, we compared the weight loss effects of drinking tea and coffee in adults