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[DOI] [PubMed] [Google Scholar] 115.Topalian SL, Sznol M, McDermott DF, Kluger HM, Carvajal RD, Sharfman WH, Brahmer JR, Lawrence DP, Atkins MB, Powderly JD, et al

Regression indicates healing incomplete or condition requiring longer treatment

That is partly about skin feel and partly about formula stability and ingredient compatibility
