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However, there is also evidence indicating that OS can be a consequence of HTN, particularly due to mechanical stress from high BP activating reactive ROS-producing enzymes, such as NOXs (Figure 2

Readers exploring how the same fragment has been proposed to act in entirely different tissues the brain, for instance can see a parallel example of preclinical-mechanism reasoning in the discussion of the molecular mechanisms proposed for AOD-9604 in obese phenotypes, where the same caution about extrapolating from limited data applies

bioRxiv2024 Apr 29

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