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In addition to these defining features, several histologic variants, such as gliosarcomas, giant-cell GBM, small-cell GBM, and epithelioid GBM, present distinct molecular and clinical implications

Vitamin C acts as a cofactor for the enzymes prolyl hydroxylase and lysyl hydroxylase, which are required for collagen formation

Furthermore, research examining the effects of ANP, a cardiac-secreted substance with multiple biological functions, on CIS-induced toxicity demonstrated that ANP administration markedly reduces BUN and creatinine levels and the urinary albumin-creatinine ratio

10.1038/nature09328 [DOI] [PMC free article] [PubMed] [Google Scholar] Chou S