Functions of glutathione
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10.1016/j.jep.2016.11.042 141 ZhangQ
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The function of the GGH encoded enzyme is to remove polyglutamates from intracellular stores of the folate derivatives that, as indicated, are predominantly stored in the liver and the kidneys
At the same time, IL-6 and TNF- secreted by TAMs (tumor-associated macrophages) promote ROS accumulation through NOX2 activation, forming a vicious cycle of oxidative stress-ferroptosis (178)
