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In addition to enhancing glucose uptake, KRAS mutations upregulate key enzymes in the glycolytic pathway that drives the conversion of glucose into pyruvate and ultimately lactate, such as HK, phosphofructokinase-1 (PFK1), and lactate dehydrogenase A (LDHA) (Fig

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Endothelial dysfunction is characterized by impaired vascular tone and homeostasis, often indicated by reduced NO production, increased oxidative stress, and elevated inflammatory responses [15]

The Hepatocyte Differentiation Basal Medium was composed of DMEM/F12, 10% KnockOut Serum Replacement (Thermo Fisher Scientific, Inc.), 1X NEAA, 1X PEST and 1X GlutaMAX Supplement (Thermo Fisher Scientific, Inc.)