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The original goal of the staple was to get the peptide into the cell, but it turns out the staple can also enhance the binding and enhance the specificity, Keating says

24 h before coincubation, mouse T cells (effector cell) were transfected with IgG/ LNP-FAPCAR 2.1 or CD5/ LNP-FAPCAR 2.1&2.2 while 3T3 cells were transfected by LNP-luciferase
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BPC-157 can help, Aziz said