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Anti-CD4 (for CD4 + T cell depletion, GK1.5, BioXcell), anti-CD8 (for CD8 + T cell depletion, 2.43, BioXcell) or mouse IgG (Control, SouthernBiotech) were intraperitoneally injected to the mice (200 g per mouse) on day 0 and 5 post the treatment

Particularly the heterodimer XPF-ERCC1, a rate-limiting factor for the NER pathway, that has single-strand DNA endonuclease activity and incises DNA on the 5 side of cisplatin adducts, and also participate in the repair of double-strand breaks induced by ICLs 11

Xu X, Griva K, Koh M, Lum E, Tan WS, Thng S, et al