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[DOI] [PubMed] [Google Scholar] 143.Hernandez D.E., Drago F., Mason G.A., Stanley D.A., Prange A.J., Jr

Understanding how peptides work at molecular levels provides biological plausibility and guides protocol development, but clinical validation through human trials remains essential for proving real-world benefits

Connective tissue investigations

Experimental findings in mouse KD models demonstrate that reduced abundance of specific Clostridium (e.g., Clostridium sensu stricto , Clostridium clusters XIVa ) correlates significantly with vasculitis progression, whereas supplementation with these Clostridium or SCFAs alleviates vascular inflammation by either activating G protein-coupled receptors (GPR43/109A) or inhibiting HDAC activity