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1 Introduction Migraine, a disorder influenced by genetics and characterized by multiple factors involving neurological, glial, and vascular systems, ranks as the second most debilitating condition worldwide, impacting the health of over one billion individuals globally (1)

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Because they are not regulated as prescription medications for these purposes, they are often sold online as "research chemicals." This lack of regulation means that the purity, potency, and safety of the products available to consumers can vary wildly

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