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In an early study performed over 40 years ago, it was found that Ancylostoma infection in humans causes platelet dysfunction, which may be associated with ADP release attenuation (324)

For instance, EVs derived from CRC perivascular cells expressed growth arrest-specific 6 (Gas6) and facilitated the recruitment of endothelial progenitor cells (EPCs) to tumors by activating the Axl pathway

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Moreover, it activates the Nrf2 pathway, inducing the expression of antioxidant and detoxification enzymes to reinforce cellular antioxidant capacity