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In adipose tissue (where NNMT is highly expressed), inhibition activates the polyamine flux pathway and shifts adipocytes toward a 'beige' phenotype with elevated energy expenditure

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Stacking & Combinations Because its mechanism is NAD+ preservation, the logical research pairing is with the NAD+ pathway : in some research framings, an NNMT inhibitor like 5-Amino-1MQ is discussed alongside NAD+ precursors, on the reasoning that inhibiting the enzyme that drains NAD+ and supplying more NAD+ substrate address the same bottleneck from two directions