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One recent publication found statins significantly reduced the risk of depressive symptoms in diabetes patients especially at the 5-year follow-up time point [210]

doi: 10.1126/science.aav7188 86 International Multiple Sclerosis Genetics Consortium (2021)

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These substitutes may be more dependence forming (such as methamphetamine), or more prone to induce overdose (such as methaqualone at grossly elevated dosages) or having properties seemingly antagonistic to those of MDMA (such as ketamine)