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A class of peptic ulcer and antacid drugs called histamine H2 receptor agonists, including Tagamet, Zantac, and Pepcid Anticonvulsants including phenobarbital, primidone, and phenytoin Bile acid sequestrants including colestipol and cholestyramine, which lower cholesterol Chemotherapy medications like methotrexate Metformin, which is a diabetes drug Proton pump inhibitor drugs used to treat acid reflux, such as omeprazole (Prilosec), esomeprazole (Nexium), or lansoprazole (Prevacid) Tetracycline, an antibiotic Lastly, it is also essential that you communicate with your provider if you have kidney disease or an allergy to cobalt or any other medication, vitamin, dye, food, or preservative

If your serum B12 is unexpectedly high despite supplementing at recommended doses, the first step is to investigate rather than immediately reduce your supplemental dose

10.3390/pharmaceutics13122055 Pharmaceutics 79 GuR.BaiL.YanF.ZhangS.ZhangX.DengR.et al (2024)

It naturally occurs in most foods, including milk and dairy, salmon, poultry, eggs, spinach, and almonds