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In addition to the changes in energy metabolism during transition in dairy cows, various studies also confirmed endocrine, hematological and immunological changes ( A better understanding of temporal hematologic changes and of the impairment of leukocyte function around parturition may be important to enhance recovery, stabilize immunologic responses, and improve energy metabolism in cows

10.1530/REP-15-0403 8

IDE-397 is another MAT2A inhibitor with low hepatotoxicity and high solubility that has shown potent modulation of SAM and symmetric dimethyarginine (SDMA) in preclinical studies

Cardiac arrhythmias in patients with AAN might increase the probability of sudden cardiac death, which is probably due to toxic effects of alcohol on a cardiac muscle that is also observed in alcoholic cardiomyopathy [168, 169]