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This publication was supported by the Open Access Publication Fund of the University of Bonn

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The net effect of the above three properties of drug on its permeability across intestinal epithelium is given as Rule of Five by Lipinski et al which is written as Molecular weight of drug 500 Lipophilicity of drug, log P 5 Number of H-bond acceptors 10 Number of H-bond donors 5 For a given drug, if any two of these values is greater than that specified above, then oral absorption may be significant problem

The researchers therefore assessed spindle morphology at multiple time points including 6, 12, and 24 hours, using 0.1 mM Epitalon
