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Many medications (for example, certain antibiotics or vaccines supplied as dry powder) need to be mixed with a specified amount of sterile water to create an injectable solution

Intramuscular placement goes deeper when large muscle groups or thick connective structures sit at the center of the plan

Clinical trials are ongoing with small-molecule TNF--converting enzyme, p38 mitogen-activated protein kinase and phosphodiesterase inhibitors that specifically interrupt the synthesis and signalling pathways for TNF- and downstream pro-inflammatory molecules such as IL-1, IL-6, nitric oxide synthase and cyclooxygenase-2