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Of note, a growing number of studies support mitochondrial metabolism of LAC as a common culprit underlying psychiatric and neurodegenerative diseases such as MDD and AD as well as obesity, making it important to further understand mechanisms for the development of aberrant mitochondrial metabolism of LAC

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At present, extensive studies have been conducted on the efficacy of L-citrulline to promote muscle functions and protein metabolism in humans and murine models [7, 130, 131, 146, 153], but this still remains a research gap yet to be explored in poultry species