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[131] The goal of dosing optimization is to achieve effective antiemetic coverage while minimizing the risk of adverse effects

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3 This is a transcriptional, hours-to-days mechanism layered on top of the acute cAMP/PKA switch, and it depends on an intact growth-hormone receptor signaling apparatus

They designed their peptide with a sequence identical to that of a segment of CDK5 known as the T loop, which is a structure critical to the binding of CDK5 to P25
