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The reasons for the wide-spread use of this test are the ease of performing the single intervention, the reproducible and spontaneous pain-related responses that can be observed in unrestrained animals, and finally, the 2 separately interpretable readouts

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Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimers disease at early pathological stage

10.1039/D1TB02757C [DOI] [PubMed] [Google Scholar] Svendsen JS, Grant TM, Rennison D, Brimble MA, Svenson J