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Despite impressive progress in cutting-edge immune monitoring techniques, multiparameter flow cytometry-based immune profiling and MRD assessment remain, at present, the fully validated and practically actionable methods for routine clinical use
Yet, these therapies fail in many patients for a variety of reasons, including CD8 + T cell exhaustion and immunosuppression by the TME due to low oxygen and competition for nutrients between tumor cells and immune cells (126)
Nat Chem Biol 4:278286
Unfortunately, patients have historically had few options for supporting their thyroid health on a routine basis
