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Shikonin, a naphthoquinone pigment derived from the traditional Chinese herbal medicine comfrey root, exhibits antioxidative properties, inhibits apoptosis, and promotes the proliferation and differentiation of neural progenitor cells

NO, a multifaceted molecule, acts as a chain-breaking antioxidant in free radical-mediated lipid peroxidation

Available online: [DOI] [PMC free article] [PubMed] [Google Scholar] 68.Chan E.S.L., Cronstein B.N

[23] have shown decreased gene expression of 26 nuclearencoded subunits of the oxidative phosphorylation chain in nondemyelinated motor cortex from MS patients, which coincided with a significant reduction in activity of NADH dehydrogenase and ubiquinolcytochrome c reductase