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Only one patient out of 406 had normal levels of both metabolites, resulting in a sensitivity of 99.8 percent when methylmalonic acid and homocysteine levels are used for diagnosis

In general mB12/LDFA has a significant influence on redox regulation with medium effect sizes, particularly in the role of positively affecting glutathione metabolism and its precursors, whereas BH4 primarily has a positive effect on markers of oxidative damage as well as methylation metabolism with large effect sizes

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As a supplement, ALA has been used to address the symptoms of various conditions such as diabetes, HIV, cancer and liver ailments