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In Europe, the European Medicines Agency supports two main regulatory tracks: well-established use and traditional use registration under Directive 2004/24/EC, which requires data on safety, efficacy, and pharmacovigilance

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doi: 10.1590/1678-9199-jvatitd-2022-0017 Summary Keywords bee venom, bee sting, clinical envenoming, clinical management, venomous animals, Africanized bee, honeybee Citation Cavalcante JS, Riciopo PM, Pereira AFM, Jeronimo BC, Angstmam DG, Pssas FC, Andrade Filho A, Cerni FA, Pucca MB and Ferreira Junior RS (2024) Clinical complications in envenoming by Apis honeybee stings: insights into mechanisms, diagnosis, and pharmacological interventions

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