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Preclinically, these inhibitors reduce infarct volumes and improve functional recovery, not merely by lowering lactate but by reprogramming cellular metabolism: forcing neurons to resurrect oxidative phosphorylation in salvageable penumbral regions and redirecting glucose toward the PPP to bolster NADPH-dependent antioxidant defenses [208, 209]

Carnitine and ALC are structurally similar to choline and Ach

[DOI] [PMC free article] [PubMed] [Google Scholar] 484.Takeshita S, Fumoto T, Naoe Y, Ikeda K

Diabetes Care 40(12):1668-77 2017 PMC5711336 Goldberg RB, Bray GA, Marcovina SM, Mather KJ, Orchard TJ, Perreault L, Temprosa M, Diabetes Prevention Program Research Group