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The Prognostic and therapeutic value and clinical implications of fibroblast activation protein- as a novel biomarker in colorectal cancer

established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present

Trial design and data sharing of standardized protocol elements and outcomes should be encouraged to support reproducibility of outcomes and meta-analysis