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The global obesity epidemic and its associated metabolic disorders urgently require more effective therapeutic interventions, particularly multi-pathway targeting therapies
Drugs 28 , 116119 (2017)

In addition to immune system-related stimuli, many extra- or intracellular disturbances can trigger regulated necrosis (Fig

The amide moiety adjacent to the covalent bond to U46 is present in two alternative conformations where the oxygen atom forms a hydrogen bond to the side chains of Trp136 and of Asn137, respectively