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The ensuing phagocytosis of RBCs may lead to iron overload within macrophages, which has been shown to cause progressive macrophage dysfunction, inflammatory M1 polarization, increased ferroptosis and exacerbated atherosclerosis 66,67,68,69,70,71

Studies show promising results for osteoarthritis when combined with hyaluronic acid, though more research is needed

For the French maritime pine bark extract Pycnogenol , cellular effects are mainly related to its anti-inflammatory and antioxidant activity and have been detailed and summarized elsewhere (39)