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Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013
OFF periods are times when dopamine levels are low in the brain, and when the medicine is wearing off or not felt when it should be, presenting as motor or non-motor fluctuations
