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In cachexia, systemic inflammation elevates hepatic hepcidin, reducing intestinal iron absorption and sequestering iron in macrophages, thereby limiting iron availability for erythropoiesis and mitochondrial oxidative metabolism in skeletal muscle ( 7.2 Treatment of ID Dietary iron is obtained from heme sourcessuch as red meat, poultry, and fishand non-heme sourcessuch as legumes, leafy greens, nuts, and fortified cereals ( Given the negative impact of ID on tumor progression and patient prognosis, iron supplementation therapy is gaining attention in the clinic

W., Huang C

drafted the Introduction, Molecular Pathways, and Conclusion sections, prepared Figure 1, and integrated all sections of the manuscript

Naryan et al