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Description
It is well known that AX and other carotenoids can modulate hepatic xenobiotic-metabolizing phase I enzymes in some species of rodents

PT2385 is one of the very few HIF-2 inhibitors investigated in preclinical models of GBM and works by preventing allosteric heterodimerization with HIF-1 when it binds to HIF-2 PAS-B domain (156)

10.1002/cmr.a.20072

[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Verma S., Hoffmann F.W., Kumar M., Huang Z., Roe K., Nguyen-Wu E., Hashimoto A.S., Hoffmann P.R