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By about one month, optimal results will likely be visible and often last around a year or longer

Neuroimage Rep 2:100095 [DOI] [PMC free article] [PubMed] [Google Scholar] 50.Heine J, Schwichtenberg K, Hartung TJ, Rekers S, Chien C, Boesl F, Rust R, Hohenfeld C, Bungenberg J, Costa AS, Scheibenbogen C, Bellmann-Strobl J, Paul F, Franke C, Reetz K, Finke C (2023) Structural brain changes in patients with post-covid fatigue: a prospective observational study

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Combined with reduced appetite making it harder to consume adequate fluids, dehydration is a real and common risk