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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Moriyuki H., Ichimura M
Key mutations in genes such as C24SMT, C5DS, and C14DM lead to the loss of ergosterol and the accumulation of other sterol precursors, which reduce the binding affinity of AmB to the parasite membrane and decrease drug sensitivity ( Leishmania (Yao and Wilson, 2016
She suggested adding a specific substance, diethylaminoethyl (DEAE)-dextran, to the agar to neutralise the anticomplementary effect
