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Temozolomide induces senescence in both human and murine glioma cells and notably contributes to the accumulation of p16 INK4 positive senescent cells in mice [60, 69]
They can affect all layers of the skin and even blood vessels, lymphatic vessels, and nerves
Metformin recipients also had significantly higher levels of homocysteine and methylmalonic acid (markers of B12 deficiency) and significantly worse scores on standardised clinical assessments of the severity of neuropathy
S.HagenE.FischerA.et al (2003)
