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Furthermore, injection of iPSCs into ischemic myocardial tissue of rats has been shown to increase cardiac ejection fraction and reduce fibrosis (241, 242)

Similar strategies may also be used to deplete IgA, as explored with the pre-clinical candidate BHV-1400 [434], which leverages ASGPR biology in a manner similar to BHV-1300 and could represent an alternative to the likely mechanism-of-action of ARGX-121, and to deplete IgE, as shown with lysosomal targeting chimeras coupling pH-sensitive target binding and ASGPR-mediated endolysosomal delivery to FcRn-mediated cellular transport of the potential therapeutic molecule [435]

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Others reach a point where they no longer want to inject every time intercourse becomes possible
